Binning metagenomic contigs by coverage and composition.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25218180.
- Also identified by DOI 10.1038/nmeth.3103.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.
Medical subject headings
- Contig Mapping
- Gastrointestinal Tract
- Genome, Bacterial
- Metagenome
- Metagenomics
- Microbiota
- Sequence Analysis, DNA
- Software