Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25224686.
- Also identified by DOI 10.1038/ncomms5874 and PMC identifier 4175578.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2. We report here the 3.5-Å resolution crystal structure of the N-terminal domain of the HCV E1 ectodomain, which reveals a complex network of covalently linked intertwined homodimers that do not harbour the expected truncated class II fusion protein fold.
Medical subject headings
- Hepacivirus
- Viral Envelope Proteins