A drug-perfluorocarbon nanoemulsion with an ultrathin silica coating for the synergistic effect of chemotherapy and ablation by high-intensity focused ultrasound.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25228225.
- Also identified by DOI 10.1002/adma.201402969.
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Abstract
The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.
Medical subject headings
- Antineoplastic Agents
- Drug Delivery Systems
- Fluorocarbons
- High-Intensity Focused Ultrasound Ablation
- Nanoparticles
- Silicon Dioxide