Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25237102.
- Also identified by DOI 10.1126/science.1256337 and PMC identifier 4372335.
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Abstract
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.
Medical subject headings
- Fetal Blood
- Hematopoiesis
- Hematopoietic Stem Cells
- Indoles
- Pyrimidines
- Receptors, Aryl Hydrocarbon
- Regeneration