Creating sub-50 nm nanofluidic junctions in a PDMS microchip via self-assembly process of colloidal silica beads for electrokinetic concentration of biomolecules.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25254651.
- Also identified by DOI 10.1039/c4lc00895b and PMC identifier 4213239.
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Abstract
In this work we describe a novel and simple self-assembly process of colloidal silica beads to create a nanofluidic junction between two microchannels. The nanoporous membrane was used to induce ion concentration polarization inside the microchannel and this electrokinetic preconcentration system allowed rapid concentration of DNA samples by ~1700 times and of protein samples by ~100 times within 5 minutes.
Medical subject headings
- Dimethylpolysiloxanes
- Microfluidic Analytical Techniques
- Nanostructures
- Nylons
- Silicon Dioxide