MTide: an integrated tool for the identification of miRNA-target interaction in plants.
basic_science · Level V
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- Record sourced from PubMed, PMID 25256573.
- Also identified by DOI 10.1093/bioinformatics/btu633.
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Abstract
Small RNA sequencing and degradome sequencing (also known as parallel analysis of RNA ends) have provided rich information on the microRNA (miRNA) and its cleaved mRNA targets on a genome-wide scale in plants, but no computational tools have been developed to effectively and conveniently deconvolute the miRNA-target interaction (MTI). A freely available package, MTide, was developed by combining modified miRDeep2 and CleaveLand4 with some other useful scripts to explore MTI in a comprehensive way. By searching for targets of a complete miRNAs, we can facilitate large-scale identification of miRNA targets, allowing us to discover regulatory interaction networks. http://bis.zju.edu.cn/MTide.
Medical subject headings
- Computational Biology
- MicroRNAs
- Plants
- RNA, Messenger
- Sequence Analysis, RNA
- Software