Complement activation in the tubulointerstitium: AKI, CKD, and in between.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25265946.
- Also identified by DOI 10.1038/ki.2014.168.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Complement activation is actively regulated to prevent injudicious activation, such as on peritubular endothelia and basolateral aspects of tubules. Miao et al. studied mice in which the key complement regulator, Crry, was deleted from tubular cells. This lacked functional consequence in unmanipulated animals. Yet, following ischemia-reperfusion, there was greater injury due to alternative pathway activation of C5. When the balance between complement activation and regulation is tipped towards the former, pathologic complement activation can ensue.
Medical subject headings
- Genetic Predisposition to Disease
- Receptors, Complement
- Reperfusion Injury