Multifunctional RNA nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25267559.
- Also identified by DOI 10.1021/nl502385k and PMC identifier 4189619.
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Abstract
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
Medical subject headings
- Nanoparticles
- RNA Interference
- RNA, Small Interfering