The contributory role of gut microbiota in cardiovascular disease.
review · Level V
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- Record sourced from PubMed, PMID 25271725.
- Also identified by DOI 10.1172/JCI72331 and PMC identifier 4215189.
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Abstract
Our group recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. A meta-organismal pathway was elucidated involving gut microbiota-dependent formation of TMA and host hepatic flavin monooxygenase 3-dependent (FMO3-dependent) formation of TMA-N-oxide (TMAO), a metabolite shown to be both mechanistically linked to atherosclerosis and whose levels are strongly linked to cardiovascular disease (CVD) risks. Collectively, these studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.
Medical subject headings
- Cardiovascular Diseases
- Intestines
- Microbiota