The effects of the shape and size of the clinical target volume on the planning target volume margin.
basic_science · Level V
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- Record sourced from PubMed, PMID 25275442.
- Also identified by DOI 10.1371/journal.pone.0109244 and PMC identifier PMC8353582.
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Abstract
PURPOSE: To investigate the impact of clinical target volume (CTV) shape and size on CTV to planning target volume (PTV) margin expansion. METHODS AND MATERIALS: Using numerical integration methods, margins accounting for random errors and systematic errors were calculated for CTVs of different shapes and sizes. We use k(r-95) and k(s-95) to represent the coefficients, for random errors and systematic errors, respectively, that ensure that every point of the CTV receives ≥95% of the prescribed dose. RESULTS: The part of the margin accounting for random errors depends on CTV shape and size; generally, a convex part of a CTV would have a larger margin than a concave part. However, the part of the margin accounting for systematic errors is independent of CTV shape and size. CONCLUSIONS: CTV shape and size should be considered when generating a PTV. For a complex CTV, the margins of the various parts of the CTV are different and related to local forms.