A big surprise in the little zygote: the curious business of losing methylated cytosines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25280211.
- Also identified by DOI 10.1016/j.stem.2014.09.005 and PMC identifier 4243610.
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Abstract
In stem cell biology, the dynamic addition and removal of 5-methylcytosines (5mCs) are necessary for lineage differentiation, nuclear reprogramming, and embryonic development. Recent investigations have sought to understand the mechanisms of how 5mCs are added and in particular how 5mCs are removed from DNA during embryogenesis.
Medical subject headings
- Cell Nucleus
- DNA Methylation
- Mammals