When old hematopoietic stem cells get damaged.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25280214.
- Also identified by DOI 10.1016/j.stem.2014.09.012.
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Abstract
Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malignancies upon aging. Two recent studies (Beerman et al., 2014; Flach et al., 2014) investigate the underlying mechanisms associated with aged HSC phenotypes and highlight DNA damage, replication stress, and ribosomal stress in the process.
Medical subject headings
- Aging
- Bone Marrow Cells
- Hematopoietic Stem Cells