Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25280215.
- Also identified by DOI 10.1016/j.stem.2014.09.010.
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Abstract
Two recent studies shed light on mechanisms underlying muscle dysfunction in age and disease. They reveal that JAK-STAT signaling regulates myogenic differentiation, leading to a reduced reservoir of muscle stem cells. Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.
Medical subject headings
- Adult Stem Cells
- Satellite Cells, Skeletal Muscle