Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25280216.
- Also identified by DOI 10.1016/j.stem.2014.09.013.
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Abstract
While cell therapies hold great potential for treating many conditions, their utility for treating patients that require whole organ replacement is unclear. To address this challenge, we propose using genetically engineered "organ niches" in large animals to generate human organs from pluripotent stem cells and discuss the hurdles facing such strategies.
Medical subject headings
- Chimera
- Organ Specificity
- Organogenesis
- Pluripotent Stem Cells