An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25295782.
- Also identified by DOI 10.1016/j.cmet.2014.09.011 and PMC identifier 4886471.
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Abstract
Reinduction of fetal gene expression is characteristic of the failing adult heart. Han et al. (2014) demonstrate that a novel cluster of long noncoding RNAs, Myheart, protects the heart from pathological hypertrophy, involving a negative-feedback molecular circuit with the epigenetic Brg1 complex to inhibit fetal-gene reactivation.
Medical subject headings
- Cardiomegaly
- Myosin Heavy Chains
- RNA, Long Noncoding