SUMOylation places LRH-1 in PROXimity to lipid metabolism.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25295783.
- Also identified by DOI 10.1016/j.cmet.2014.09.008.
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Abstract
The development of atherosclerosis is countered by the reverse transport of cholesterol from peripheral tissues to the liver for excretion. In this issue of Cell Metabolism, Stein et al. (2014) establish LRH-1 as an important regulator of reverse cholesterol transport and identify SUMOylation as a primary mode of LRH-1 regulation.
Medical subject headings
- Cholesterol
- Homeodomain Proteins
- Liver
- Receptors, Cytoplasmic and Nuclear
- Tumor Suppressor Proteins