Muscle over mind.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25295784.
- Also identified by DOI 10.1016/j.cmet.2014.09.012 and PMC identifier 6016023.
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Abstract
Depression is associated with elevated kynurenine levels, a tryptophan metabolite generated under stress and inflammatory conditions. Agudelo et al. (2014) now reveal how PGC-1α1 overexpression in muscle mimics anti-depressant effects of exercise by promoting kynurenine aminotransferase expression, likely preventing kynurenine from crossing the blood brain barrier to disrupt neural plasticity.
Medical subject headings
- Depression
- Kynurenine
- Muscle, Skeletal
- Stress, Psychological
- Transcription Factors