The impact of JAK-STAT signaling on muscle regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25295935.
- Also identified by DOI 10.1038/nm.3720 and PMC identifier 4426494.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Altered stem cell homeostasis underlies functional tissue decline during muscle aging and disease progression. Janus kinase–signal transducer and activator of transcription (JAK-STAT) signal transduction is a crucial regulator of muscle regeneration, and targeting this pathway in mice relieves aspects of debilitating muscle wasting.