Klebsiella pneumoniae carrying bla NDM-1 gene in orthopedic practice.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25298566.
- Also identified by DOI 10.4103/0019-5413.139888 and PMC identifier 4175873.
- Licence recorded as CC BY-NC-SA.
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Abstract
Emergence and spread of carbapenemases in Enterobacteriaceae is a cause of concern worldwide, the latest threat being New Delhi metallo-β-lactamase (NDM-1). This report is of an orthopedic case with fracture femur managed with internal fixation and bone grafting, who subsequently developed secondary infection with Klebsiella pneumoniae harboring bla NDM-1 gene. Minimum inhibitory concentration (MIC) of imipenem was ≥8 μg/ml by E-test, suggestive of carbapenemase production. Phenotypic and further genotypic detection confirmed the presence of bla NDM-1 gene. The isolate remained susceptible only to tigecycline, colistin, and polymyxin B.