Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring".
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- Record sourced from PubMed, PMID 25301611.
- Also identified by DOI 10.1126/science.1256009.
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Abstract
Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.
Medical subject headings
- Autistic Disorder
- Cytoprotection
- Oxytocin
- gamma-Aminobutyric Acid