Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25303520.
- Also identified by DOI 10.1016/j.cell.2014.09.023 and PMC identifier 7031110.
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Abstract
Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.
Medical subject headings
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Cyclic AMP Response Element-Binding Protein