Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25323443.
- Also identified by DOI 10.1002/adma.201403415.
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Abstract
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
Medical subject headings
- Nanoparticles
- Photochemotherapy
- Photosensitizing Agents
- Porphyrins
- Silicon