CpG-loaded multifunctional cationic nanohydrogel particles as self-adjuvanting glycopeptide antitumor vaccines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25327631.
- Also identified by DOI 10.1002/adhm.201400460.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.
Medical subject headings
- Adjuvants, Immunologic
- Cancer Vaccines
- Glycopeptides
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Nanoparticles
- Oligodeoxyribonucleotides