Integration of nanoassembly functions for an effective delivery cascade for cancer drugs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25328159.
- Also identified by DOI 10.1002/adma.201401554.
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Abstract
A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.
Medical subject headings
- Antineoplastic Agents
- Dendrimers
- Drug Delivery Systems
- Nanostructures