A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25333768.
- Also identified by DOI 10.1021/nl502994y and PMC identifier 4245989.
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Abstract
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
Medical subject headings
- Anti-Inflammatory Agents
- Delayed-Action Preparations
- Hypoglycemic Agents
- Insulin
- Interleukin-10
- Nanoparticles
- Polymers