minimac2: faster genotype imputation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25338720.
- Also identified by DOI 10.1093/bioinformatics/btu704 and PMC identifier 4341061.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Genotype imputation is a key step in the analysis of genome-wide association studies. Upcoming very large reference panels, such as those from The 1000 Genomes Project and the Haplotype Consortium, will improve imputation quality of rare and less common variants, but will also increase the computational burden. Here, we demonstrate how the application of software engineering techniques can help to keep imputation broadly accessible. Overall, these improvements speed up imputation by an order of magnitude compared with our previous implementation. minimac2, including source code, documentation, and examples is available at http://genome.sph.umich.edu/wiki/Minimac2
Medical subject headings
- Computational Biology
- Genome-Wide Association Study
- Genotype
- Software