Galectin-1 and immune suppression during radiotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25348514.
- Also identified by DOI 10.1158/1078-0432.CCR-14-2702.
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Abstract
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
Medical subject headings
- Apoptosis
- Carcinoma, Non-Small-Cell Lung
- Galectin 1
- Lung Neoplasms
- Lymphopenia