Closing in on a mechanism for activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25350976.
- Also identified by DOI 10.7554/eLife.04909 and PMC identifier 4210822.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.
Medical subject headings
- Insulin-Like Growth Factor I
- Receptor, IGF Type 1