A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.
basic_science · Level V
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- Record sourced from PubMed, PMID 25353349.
- Also identified by DOI 10.1371/journal.pone.0109361 and PMC identifier PMC1257538.
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Abstract
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.