Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 25362202.
- Also identified by DOI 10.1093/cid/ciu795 and PMC identifier 4293395.
- Licence recorded as CC BY-NC-ND.
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Abstract
Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.
Medical subject headings
- Antigens, Bacterial
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Mycobacterium tuberculosis
- Tuberculosis