A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25363160.
- Also identified by DOI 10.1002/adma.201403877.
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Abstract
A novel reduction and pH dual-sensitive nonviral vector for long-circulating and tumor-targeted siRNA delivery is described. The nanomedicine is negatively charged at neutral pH of bloodstream whereas it is positively charged at lower pH of tumor tissue (ca. 6.8). Interlayer crosslinking with disulfide bonds stabilizes the nanomedicine during blood circulation and allows quick intracellular siRNA release after endocytosis.
Medical subject headings
- Genetic Vectors
- Polymers
- RNA, Small Interfering