Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25365074.
- Also identified by DOI 10.1172/JCI78891 and PMC identifier 4347251.
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Abstract
During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-β, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.
Medical subject headings
- Allergens
- Immune Tolerance
- Interleukin-10
- T-Lymphocytes, Regulatory