Deciding whether follow-up studies have replicated findings in a preliminary large-scale omics study.
other · Level V
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- Record sourced from PubMed, PMID 25368172.
- Also identified by DOI 10.1073/pnas.1314814111 and PMC identifier 4246311.
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Abstract
We propose a formal method to declare that findings from a primary study have been replicated in a follow-up study. Our proposal is appropriate for primary studies that involve large-scale searches for rare true positives (i.e., needles in a haystack). Our proposal assigns an r value to each finding; this is the lowest false discovery rate at which the finding can be called replicated. Examples are given and software is available.