Multilayered polyelectrolyte microcapsules: interaction with the enzyme cytochrome C oxidase.
basic_science · Level V
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- Record sourced from PubMed, PMID 25372607.
- Also identified by DOI 10.1371/journal.pone.0112192 and PMC identifier PMC3147519.
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Abstract
Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase molecules was investigated. We found that the cytochrome c oxidase retained its functionality, that the functionalized microcapsules interacting with cytochrome c oxidase were permeable and that the permeability characteristics of the microcapsule shell depend on the shell components. This work provides a significant input towards the fabrication of an integrated device made of biological components and based on specific biomolecular functions and properties.