Monitoring cerebral hemodynamics following optogenetic stimulation via optical coherence tomography.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25373076.
- Also identified by DOI 10.1109/TBME.2014.2364816.
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Abstract
In this article, spectral domain optical coherence tomography is used to measure the hemodynamic response induced by optogenetic stimulation in the somatosensory cortex of transgenic mice. By analyzing the 3-D angiograms and Doppler measurements produced by coherence tomography, we observed significant increase in blood flow as a result of increased vessel diameter and blood velocity following optical stimulation of cortical neurons. Such distinct responses were not observed in control experiments where the brain of wild-type mice were exposed to the same light pulses.
Medical subject headings
- Blood Flow Velocity
- Brain
- Cerebrovascular Circulation
- Optogenetics
- Photic Stimulation
- Tomography, Optical Coherence