A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.

Fairbanks, Benjamin D; Schwartz, Michael P; Halevi, Alexandra E; Nuttelman, Charles R; Bowman, Christopher N; Anseth, Kristi S · Adv Mater · 2009

basic_science · Level V

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Abstract

Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.