Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25378176.
- Also identified by DOI 10.1002/adhm.201400410 and PMC identifier 4384641.
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Abstract
Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells.
Medical subject headings
- Cell Culture Techniques
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Induced Pluripotent Stem Cells
- Neural Stem Cells