Rapid modulation of droplet composition with pincer microvalves.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25385230.
- Also identified by DOI 10.1039/c4lc01040j and PMC identifier 5531040.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Single-layer membrane valves are simple to fabricate and to integrate into microfluidic devices. However, due to their rectangular flow channel geometry, they do not fully seal. Here, we show that liquid flow can be reduced by over 3 orders of magnitude, enabling the contents of forming droplets to be dynamically modulated. We use this precision control to perform combinatorial DNA synthesis in the droplets.
Medical subject headings
- Microfluidic Analytical Techniques