Fast and sensitive protein alignment using DIAMOND.
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Where this comes from
- Record sourced from PubMed, PMID 25402007.
- Also identified by DOI 10.1038/nmeth.3176.
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Abstract
The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.
Medical subject headings
- Metagenomics
- Sequence Alignment
- Software