Osteoactivin attenuates skeletal muscle fibrosis after distraction osteogenesis by promoting extracellular matrix degradation/remodeling.
basic_science · Level V
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- Record sourced from PubMed, PMID 25405936.
- Also identified by DOI 10.1097/BPB.0000000000000117.
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Abstract
The aim of this study was to determine whether osteoactivin attenuated skeletal muscle fibrosis caused by distraction osteogenesis. Tibial osteotomies were performed on wild-type and osteoactivin-transgenic (OA-Tg) mice, and tibiae were distracted for 2 weeks. Ankle plantar flexion torque and the gastrocnemius muscles were analyzed. The amount and area of collagenous tissue and the passive torque were reduced in the OA-Tg group at 8 weeks after osteotomy. Transcript levels of matrix metalloprotease (mmp)-3 and MMP-9 were upregulated, and MMP-3 and MMP-9 proteins were increased in the OA-Tg group. Osteoactivin-mediated increase in MMPs may attenuate skeletal muscle fibrosis.
Medical subject headings
- Extracellular Matrix
- Eye Proteins
- Fibrosis
- Membrane Glycoproteins
- Muscle Strength
- Muscle, Skeletal
- Osteogenesis, Distraction
Anatomy
- ankle
- tibia