Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 25413444.
- Also identified by DOI 10.1002/adma.201404235.
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Abstract
A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified "aptamer monomer" results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.
Medical subject headings
- Aptamers, Nucleotide
- Molecular Imprinting
- Nanoparticles
- Polymers