Characteristics and quantities of HIV host cells in human genital tract secretions.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25414414.
- Also identified by DOI 10.1093/infdis/jiu390 and PMC identifier 4303079.
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Abstract
Human immunodeficiency virus (HIV)-infected leukocytes have been detected in genital secretions from HIV-infected men and women and may play an important role in the sexual transmission of HIV. However, they have been largely overlooked in studies on mechanisms of HIV transmission and in the design and testing of HIV vaccine and microbicide candidates. This article describes the characteristics and quantities of leukocytes in male and female genital secretions under various conditions and also reviews evidence for the involvement of HIV-infected cells in both horizontal and vertical cell-associated HIV transmission. Additional research is needed in this area to better target HIV prevention strategies.
Medical subject headings
- Genitalia, Female
- Genitalia, Male
- HIV