Defined patterns of neuronal networks on 3D thiol-functionalized microstructures.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25415470.
- Also identified by DOI 10.1021/nl502922b.
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Abstract
It is very challenging to study the behavior of neuronal cells in a network due to the multiple connections between the cells. Our idea is then to simplify such a network with a configuration where cells can have just a fixed number of connections in order to create a well-defined and ordered network. Here, we report about guiding primary cortical neurons with three-dimensional gold microspines selectively functionalized with an amino-terminated molecule.
Medical subject headings
- Metal Nanoparticles
- Molecular Imprinting
- Nerve Net
- Neurons
- Sulfhydryl Compounds
- Tissue Array Analysis