Genetic variation meets replication origins.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25416936.
- Also identified by DOI 10.1016/j.cell.2014.11.009.
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Abstract
Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.
Medical subject headings
- Polymorphism, Genetic
- Quantitative Trait Loci