HIV-1 Packing to Leave.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25416937.
- Also identified by DOI 10.1016/j.cell.2014.11.008.
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Abstract
HIV-1 virion assembly at the plasma membrane requires the selective recruitment of the viral RNA genome into nascent viral particles while cellular transcripts are excluded. Kutluay et al. now demonstrate that this is a two-step process in which Gag binds sequentially to different sites on the viral genome.
Medical subject headings
- HIV-1
- RNA, Viral
- gag Gene Products, Human Immunodeficiency Virus