Stealing VEGF from thy neighbor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25417099.
- Also identified by DOI 10.1016/j.cell.2014.10.008.
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Abstract
The distribution and patterning of blood vessels is controlled by vascular endothelial growth factor (VEGF), which is precisely regulated throughout its life cycle. Okabe et al. show that VEGF is titrated away from the endothelium by adjacent neurons via endocytosis, regulating density and trajectory of blood vessels.
Medical subject headings
- Neovascularization, Physiologic
- Neurons
- Retina
- Vascular Endothelial Growth Factor A