Building robust transcriptomes with master splicing factors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25417102.
- Also identified by DOI 10.1016/j.cell.2014.09.054 and PMC identifier 4243530.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.
Medical subject headings
- Gene Expression Regulation, Developmental
- RNA Splicing
- RNA-Binding Proteins