SnapShot: the germinal center reaction.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25417116.
- Also identified by DOI 10.1016/j.cell.2014.10.012.
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Abstract
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
Medical subject headings
- Antibodies
- Germinal Center