Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25419708.
- Also identified by DOI 10.1038/nm.3715 and PMC identifier 4257865.
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Abstract
α4β7 integrin-expressing CD4(+) T cells preferentially traffic to gut-associated lymphoid tissue (GALT) and have a key role in HIV and simian immunodeficiency virus (SIV) pathogenesis. We show here that the administration of an anti-α4β7 monoclonal antibody just prior to and during acute infection protects rhesus macaques from transmission following repeated low-dose intravaginal challenges with SIVmac251. In treated animals that became infected, the GALT was significantly protected from infection and CD4(+) T cell numbers were maintained in both the blood and the GALT. Thus, targeting α4β7 reduces mucosal transmission of SIV in macaques.
Medical subject headings
- Antibodies, Monoclonal
- CD4-Positive T-Lymphocytes
- DNA, Viral
- Integrins
- Intestinal Mucosa
- Lymphoid Tissue
- Simian Acquired Immunodeficiency Syndrome
- Vagina