Acoustic force spectroscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25419961.
- Also identified by DOI 10.1038/nmeth.3183.
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Abstract
Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.
Medical subject headings
- Acoustics
- Spectrum Analysis